SPARC: Minimally Invasive Recording of Neural Activity During Natural Voiding in Anaesthetized Rats

Abstract

Background Controlling urination with bioelectric neuromodulation devices is an emerging treatment strategy for bladder incontinence/retention as it can be rapidly adjusted to respond to changing patient needs, known as closed‐looped control. However, true closed‐loop bioelectric neuromodulation requires sensing of neural activity to allow accurate and timely delivery of the stimulation to maximally affect the end‐organ. As such, developing a neural recording feedback system that is highly specific for different neural fibre types is a crucial first step towards closed‐loop control. Objective To..